By proton pump inhibitor is a group of pharmacological agents that reduce the intensity of the secretion of hydrochloric acid in the stomach.Having a direct impact on the secretory tubules, they effectively lead to the desired therapeutic effect ulcers, erosive gastritis, GERD.The group includes a set of drugs, similar in chemical structure but having different pharmacodynamic parameters, i.e. medicines are almost identical to the secretory cells, but do so in different concentrations and with different speeds.
Proton pump inhibitors: the moments of the molecular effect of drugs
proton pump is a complex protein structure that regulates penetration of hydrogen ions into the lumen of the stomach.It consists of two chemically dissimilar elements, otherwise called subunits.The first is solely constructed of protein and amino acids.In the lining membrane cell, it behaves in a special way, crossing it 10 times, resulting in a 5-channel secretory loops.Passing through the cavity of ions get into the lumen of the stomach and provide acidification of the environment and the fall pH value.Thus it is in one of the loops is the active center of the protein - a sequence of 800 amino acids, which catalyzes the breakdown of ATP, the main energy of the substrate cell.
another subunit is a protein complex that is composed of the polypeptide sequence, respectively a certain ordered structure and glycoprotein chains.The overwhelming part of the molecule is outside the cytoplasm, and the glycoprotein part is probably ekstratsitoplazmaticheskim receptor complex that picks up the signal of the activation of the enzyme H + \ K + -ATPase.When this protein crosses the membrane moiety once, suggesting its value as a connecting element between the outer and the first receptor subunit that is responsible for conducting the catalytic reaction for the synthesis of protons.
Accordingly, the structure of the proton pump secretory tubules of parietal cells can be concluded about how a simple way you can suppress the secretion of H + into the cavity of the body.The most justified option - it is the inhibition of the enzyme responsible for the synthesis, which is what proton pump inhibitors .
inhibitors in clinical practice
In medicine proton pump inhibitors are widely used, especially in gastroenterology, due to their ability to reduce the acidity of gastric secretion, and thus reduce the intensity of the damaging effects on the stomach wall, which is especially importantwhen inflammation.Wherein the therapeutic effect is independent of the etiology of the inflammatory process, as it is removed by the aggressive influence of the environment on the integrity of the organ.Also, the spectrum of abnormalities for effective treatment that uses proton pump inhibitors has been expanded by a stomach ulcer and duodenal ulcer, erosive GERD and non-erosive forms.
Among the most common medications include proton pump inhibitors with the following generic names omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, and others.Among them are trade names, such as "Omez."Medicaments available in capsule form.They are ingested in a prescribed specialist dosage that varies depending on the particular type of pathology.This allowed self-administration, as there is a group of patients who complain of seasonal exacerbation of chronic gastric or duodenal ulcers.In other cases, the reception is negotiated with the doctor during the reception.
