During the period of antibiotics appeared many bacteria that produce substances that inhibit their action.To combat some of these microorganisms used drug "Oxacillin" instructions for use which is considered in this article.
composition and function
Oxacillin - is an antibiotic belonging to the semisynthetic penicillins.Under its action takes place blocking the process of cell wall synthesis of bacteria, destruction of dividing bacterial cells.It is active against Gram-positive microorganisms, includingand those that produce penicillinase - a substance that the inhibitory effect of penicillin.Among them the targeted bacteria include Staphylococcus, Streptococcus, gram-negative cocci, anaerobic spore-forming bacillus.In the majority of Gram-negative organisms medicine "Oxacillin" does not apply.
Dosing
Medicine "Oxacillin" User Application Tips used for infections caused by Gram-positive microorganisms:
- sinusitis,
- sepsis,
- abscess,
- cholecystitis,
- phlegmons,
- pyelitis,
- osteomyelitis,
- cystitis,
- and postoperative wound infections,
- infected burns,
- bacterial endocarditis,
- meningitis.
There are two forms of the drug issue "Oxacillin": tablets and solution for injection.
Tablets are encouraged to take an hour before a meal.For adults, the maximum dose of 3 grams per day.Duration of treatment 7 to 10 days, with severe pathologies may be extended up to 3 weeks.
solution was administered intramuscularly and intravenously.Dosage - from 2 to 4 grams of the drug daily.Intramuscular 0.25 gram bottle of oxacillin was diluted with 1.5 ml water for injections.When administered intravenously, 0.25 to 5 g of the drug is dissolved in 5 ml of sodium chloride or water for injection.It is also possible drip of medicine.
exact dosage of the solution and tablets appointed doctor.
Contraindications and side effects
for preparation "Oxacillin" User names the following contraindications.It can not be taken in case of hypersensitivity, as well as in cases when the body can not tolerate beta-lactam antibiotics.Precautions should be taken drug in diseases such as bronchial asthma, enterocolitis, allergies, as well as kidney disease.Nursing and expectant mothers drug "Oxacillin" instructions for use and the Council are appointed only in extreme cases.With his admission during breastfeeding should go to the artificial baby food.Do not use the drug to treat infections caused by micro-organisms sensitive to benzylpenicillin.
Before the drug can occur a number of side effects.These include nausea, vomiting, diarrhea, allergic reactions (rash, pruritus).When you assign a daily dose of more than 6 grams of this medication has hepatotoxic effects on the body: nausea, vomiting, hyperthermia, skin becomes jaundiced.For preparation "Oxacillin" instruction on the application specifies such side effects as proteinuria, hematuria, interstitial nephritis.When administered intravenously, it may cause thrombophlebitis.
There are some limitations when using the drug in conjunction with other medications.Under its action increases the toxicity of methotrexate due to the fact that both the drug fighting for tubular secretion.At the same time taking oxacillin and calcium folinate may be necessary to increase the dose of antidote to folic acid antagonists.You can not assign the medicine, and in conjunction with drugs that have pronounced hepatotoxicity.Also, simultaneously with the means "Oxacillin" not recommended bacteriostatic antibiotics - in this case, reduces its effectiveness.At the same time taking an antacid and laxative medication decreases the absorption of its gastrointestinal tract.
