benzoic acid was first isolated from the resin of the same name, which contains about 80% of the active substance.In the late 20th century, the substance obtained synthetically.Benzoic acid is a member of various herbs, berries and fruits.Large quantities of the substance contained in the urine as a herbivore biosoedineny with glycine (hippuric acid).
benzoic acid synthesized in the human body and part of proteins excreted in urine as hippuric acid.Of benzene acid exhibits antiseptic, fungicidal and local irritating effect.When injected into the bloodstream it shows antipyretic effect.Couples said acid irritate the mucous membranes of the respiratory tract, so it can be released in part of the bronchial mucosa.Acid sodium salt of benzene can be used as an expectorant.Externally - as an anti-parasitic agent.
of benzene due to the neutralization of the acid solution of sodium bicarbonate (baking soda), sodium benzoate is obtained.Subsequently, the mixture is evaporated to form crystals.The resulting solutions are slightly alkaline reaction.
sodium benzoate: properties.
needle crystals or powder dissolved in two parts of water, 45 parts and 13 parts of the cold boiling ethanol, in nine parts of glycerol.
identification.
Sodium ions are identified by the yellow color of the flame when burning the preparation.Benzoate ions recorded by reaction with a solution of ferric chloride.Because the drug is isolated benzoic acid and its melting temperature is checked.
sodium benzoate: testing for purity.
The preparation is tested for acidity and alkalinity limits.By the standards of tolerance of impurities of heavy metals, sulfates, chlorides.
sodium benzoate: quantification.
weighed sample of the drug to dissolve in the water, then add a few drops of ether and mixtures indicators (methyl orange and methylene blue) and shake.The concentration of sodium benzoate in the drug should be at least 99%.
Caffeine-sodium benzoate: application.
Said means prescribed as a stimulator of the central nervous system.Caffeine regulates the excitation of the cortex activates positive reflexes, motor activity increases.This pharmacodynamics improves mental and physical performance and reduces sleepiness and fatigue.The maximum dose of caffeine can lead to depletion of neurocytes.The drug reduces the effect of narcotic and hypnotic drugs, activates spinal reflex excitability, raises vasomotor and respiratory centers.Use of the drug enhances diuresis and cardiac function.
mechanism of action of caffeine sodium benzoate.
Caffeine inhibits phosphodiesterase activity.This in turn leads to Escrow intracellular c-AMP (cyclic adenozinmonofasfat).c-AMP activates glycogenolysis, increases metabolic reactions in tissues and organs, including muscles and the central nervous system.A key element in the mechanism of the stimulating effect of the drug is binding (interaction) with caffeine purine receptors in the brain.The drug is rapidly absorbed in the gut.In the process of biochemical reactions and the drug is oxidized demethylates.Excreted by the kidneys.
Food preservatives used to extend the shelf life of food products.Since E211 (sodium benzoate) exhibits bactericidal against bacteria, fungi and yeast, so it is used as a preservative.There he is in non-carbonated and carbonated beverages, fruit juices, olives, syrups.The natural products contained in cinnamon, apples, cranberries, raisins, cloves.
