Magnesium can be ingested in the form of salts (magnesium oxalate) or chelates (chlorophyll, phytin).Absorption occurs in said mineral ionized in the duodenum.A significant amount of mineral in the human body is concentrated in the teeth and bones of the skeletal muscle.It should be noted that magnesium - an intracellular ion.
When hypomagnesemia magniyzavisimyh reduced activity of enzymes inhibited the metabolism of carbohydrates and phosphorus.Clinically it may appear as an extension of the peripheral blood vessels, acceleration of heart rate, congestion of the mucous membranes, cardiac dysfunction.
Exchange Magnesium is closely related to the level of calcium and phosphorus in the body, and its pharmacodynamics dependent on the routes of administration of drugs of magnesium.For parenteral administration in small doses of magnesium ions is controlled acid-base balance and the osmotic pressure of the intracellular and extracellular fluids.It takes part in redox reactions, increases the reactivity of the neuromuscular system.This macro element is an integral component of many enzymes, provides cellular respiration, regulates the metabolism of carbohydrates and proteins.The maximum dose of magnesium inhibit the reactivity of neurons and exhibit a sedative or narcotic effect.Magnesium is an antagonist of calcium.Last displaces magnesium ions from the nerve cells, calcium, magnesium eliminates the narcotic effect.
Epsom salt was first synthesized English botanist N. Grew in 1695.Later (1710) it began to receive from seawater.Magnesium sulfate is found in nature in various minerals.Quite a lot of this mineral in the Caucasus, in Siberia and the Kuban.Epsom salt is usually obtained from magnesite.It is often found in magnesium sulfate brines attorney salt as an impurity.Especially high concentrations found in the waters of the Caspian Sea.In the process of dissolving the oxide of magnesium sulfate, magnesium sulfate acid produced.Purification of the resulting salt is carried out by recrystallization.
salts of magnesium sulfate - colorless prismatic crystals, bitter-salty taste, readily soluble in water.Epsom salt contains 35% water of crystallization, which quickly disappears during heating.Solutions are neutral, thermally stable.Release form of the drug - 25% solution or powder.
Epsom salt: the mechanism of action
salts (magnesium sulfate) are poorly absorbed, absorb and hold water on its surface.The result is indicated pharmacodynamics laxative effect.This preparation is stronger than the sodium sulfate irritates the mucous membranes and causes hyperemia of the intestine.Partly soaked, magnesium sulfate affects the liver and operates bilious.For parenteral administration, Epsom salt has a calming (sedative) effect on the central nervous system and in higher doses induces sleep or general anesthesia.Action magnesium sulfate is removed by the introduction of calcium supplementation.Calcium ions are displaced from the cells magnesium ions, thus leveled their narcotic effect.
Epsom salt: use
When using the drug orally in small doses improves digestion, activates the flow of bile.In large doses, Epsom salt causes diarrhea.Magnesium sulfate is used as a cholagogue spasm of the bile duct wall.For enteral administration (15-25 g) is manifested laxative action by parenteral (subcutaneously in a dose of 10 ml 5-20% solution twice a day) - the narcotic effect.Epsom salt can also be applied topically for purulent processes (abscess, cellulitis, weeping ulcers, infected wounds).For this purpose, hypertonic solutions with a concentration of 15-25%.
