"mefenamic acid" - a drug widely used in arthrology, treatment of diseases of infectious and inflammatory nature, relieving the symptoms of brain.
This drug belongs to a group of pharmacological agents fenamates - substances that have an anti-inflammatory effect."Mefenamic acid" has established itself as an excellent antipyretic and analgesic.
drug has a complex mechanism of action involves direct participation in the inflammatory response."Mefenamic acid" (active substance) reduces the synthesis of specific substances (mediators), which include the prostaglandins, kinin, serotonin.Furthermore, it significantly reduces the proteolytic activity of lysosomal enzymes, participating directly in the first two phases of inflammation: exudation, proliferation.Other effects of this drug include: stabilization of cell membranes and protein ultrastructure, decrease vascular permeability and swelling of affected tissues, increasing serotonin activity, increased resistance of cells, stimulation of regeneration processes.Analgesic effect of the drug is in a direct influence on the central mechanism of pain sensitivity, as well as local action on the inflammatory focus.Antipyretic properties associated with direct blocking prostaglandin synthesis, effects on the thermoregulatory center in the brain.Another feature is to stimulate the production of interferon, which directly enhances the proliferative properties of the active substance.
mefenamic acid has a fairly high rate of absorption.The maximum concentration is reached after two to four hours after ingestion.The level of drug in the blood is always proportional to the dose received it.Transport in the bloodstream of the drug occurs by binding to albumin.The half-life of the active material is three hours.Approximately sixty percent excreted in the urine almost unmodified form, twenty-five - with the feces.
"mefenamic acid" has a fairly broad spectrum of action, which is due to a variety of effects that has the active ingredient.The main diseases with symptoms that can cope quite well this drug are nonspecific polyarthritis, acute rheumatism, neuralgia, myalgia, arthralgia, ankylosing spondylitis, cold, periodontitis.The drug is also intended for the relief of headaches, toothaches, bouts of fever, signs of disorders of the menstrual cycle.
for "mefenamic acid" there are a number of contraindications, basic of which are hypersensitivity, the presence of duodenal ulcer and gastric inflammatory diseases of the gastrointestinal tract, the blood, the kidneys.During pregnancy, lactation should be limited by the use of this drug.
interaction with other groups of drugs - yet another feature, which is characterized by mefenamic acid.Guide to the preparation describes in detail all the possible reactions and complications.In conjunction with the "Analgin" and salicylates enhanced anti-inflammatory effect.The drug also increases the prothrombin time when taking anticoagulants.
main side effects that have mefenamic acid, are disorders of the gastrointestinal tract, manifested dyspeptic and motor impairments.With prolonged use of the drug may develop hemolytic anemia type.
